Trials Open for Recruitment

Trials Open for RecruitmentBeating the Blues before Birth

Welcome to the Beating the Blues before Birth (BBB) study for depression in pregnancy.

You have taken a positive step towards improving your mood and managing the demands of pregnancy.

This study evaluates the impact of PIRI’s evidence-based cognitive behavioural therapy (CBT) on the mother and baby. Your participation is highly valued and will help advancing research.

You will receive a clinical assessment and 8 free sessions of CBT delivered by a psychologist via telehealth (to learn more about our evidence-based treatment please read below).


You will receive a clinical assessment with a psychologist and will be encouraged to see your GP and/or other health professionals for best-care management.

  • You will be randomly allocated to one of the two study groups mentioned above (i.e., CBT or referral to your GP/another health professional)
  • As this is a research project you will not be able to choose which group you will be in
  • Participation in both groups is highly valuable for successfully conducting the study.
  • You will be contacted by the project manager to book in a telephone assessment with the study psychologist to determine whether the study is suitable for you
  • During the telephone assessment you will be asked some questions about your mood and mental health.
  • You will be asked to complete questionnaires at 4 time points with the last follow-up carried out at 2 years after your child will be born
  • You will receive $20 for every time you will complete the follow-up questionnaires.

The study is suitable for women who are experiencing depression in pregnancy and are:

  • Less than 30 weeks pregnant
  • Not currently receiving treatment for depression or anxiety (either psychotherapy or medication)
  • Over 18 years of age
  • Fluent in English

BBB program has been developed by the Parent-Infant Research Institute as a treatment for depression in pregnancy. This program is based on PIRI’s evaluated treatment for Postnatal Depression and includes features from other PIRI programs. Our recent studies show the effectiveness of BBB in reducing depression and anxiety during pregnancy and in improving child developmental outcomes.

Milgrom, J., Holt, C., Holt, C.J., Ross, J., Ericksen, J., & Gemmill, A. (2015). A Feasibility Study and Pilot Randomised Trial of an Antenatal Depression Treatment with Infant Follow-up. Archives of Women’s Mental Health, 18(5):717-30. Milgrom,  J., Holt, C.J., Bleker, L.S., Holt, C., Ross, J., Ericksen,  J., Glover, V., O’Donnell, K.J., de Rooij, S. R., & Gemmill , A.W. (2018). Maternal antenatal mood and child development: an exploratory study of treatment effects on child outcomes up to 5 years. Journal of Developmental Origins of Health and Disease.


DadBooster is designed to help new dads recover from depression.

The Parent-Infant Research Institute (PIRI) are working on a world-first specialised web-based treatment called DadBooster for fathers who are experiencing symptoms of depression and anxiety.

Our DadBooster study is open for recruitment. To find out more and join the study, click the link below.