EVALUATING INTERVENTIONS IN RCTs DURING THE PERINATAL PERIOD

A focus of PIRI’s research is the production of validated interventions that are brief, cost-effective and translatable into every-day practice. PIRI has conducted numerous randomised, controlled trials to produce brief interventions for ante and postnatal depression. This includes programs targeting both the mental health of mothers and infants.

PIRI researchers published the first evidence from a RCT that treating maternal depression in pregnancy can promote better developmental outcomes in children (Milgrom et al., 2015). We subsequently published a follow-up in later childhood (Milgrom, Holt, et al., 2019) and currently have 2 more manuscripts published and in press at peer-reviewed journals reporting on genome-wide methylation patterns and structural brain differences in children of treated and untreated mothers (Bleker et al., 2019a;. Bleker et al., 2019b; Milgrom, Holt, et al., 2019).

Currently we are undertaking a large, NHMRC-funded RCT, Beating The Blues Before Birth, addressing this critical question.